Description:
This post describes how to delete a file from multiple user profiles (normal.dot in this example). Also has the ability to exclude certain profile folders. Could be easily combined with this script to delete folders/subdolfers and files from each profile: Delete a Folder and its Subfolders
Source:
Script:
' Sample VB Script to remove a designated file (default is NORMAL.DOT) located in the profile folder for every user on the
 ' system. There is provision for exempting certain folders via the constant ProtectedUsers which is set to a comma separated
 ' list which can be altered according to your requirements
 '
 ' You should alter constant DeleteProtectedUsers from FALSE to TRUE to delete *ALL* copies of the file regardless of profile
 ' 
Const FileToDelete        = "Normal.DOT"
 Const AllUsers            = "\All Users"
 Const DeleteProtectedUsers = "FALSE"
 Const TemplatesFolder      = "Application Data\Microsoft\Templates"
 Const ProtectedUsers      = "Default User,Administrator,All Users,NetworkService,LocalService"
 Dim oFSO, oWSH
 Dim sAllUsersProfile, oAllUsersFolder, sProfilesRoot, oFolder
 Dim colFSOSubFolders 
Dim protuserarray
 Dim DeleteFlag
 On Error Resume Next ' this is set because the designated file may be locked from deletion
 protuserarray = Split(ProtectedUsers,",")
 ' Instantiate the objects
 Set oFSO    = CreateObject("Scripting.FileSystemObject")
 set oWSH    = CreateObject("WScript.Shell")
 ' Get the Allusers profile folder path first and from this determine profiles parent folder
 '
 sAllUsersProfile    = oWSH.ExpandEnvironmentStrings("%ALLUSERSPROFILE%")
 Set oAllUsersFolder = oFSO.GetFolder(sAllUsersProfile)
 sProfilesRoot      = oAllUsersFOlder.ParentFolder
 ' Now enumerate all existing user profile folders
 Set oFolder            = oFSO.GetFolder(sProfilesRoot)
 Set colFSOSubfolders  = oFolder.Subfolders
 ' Now go through each existing user profile folder looking for the designated file to delete
 For Each objSubfolder in colFSOSubfolders
   DeleteFlag = "TRUE"
   if oFSO.FileExists(sProfilesRoot & "\" & objSubfolder.Name & "\" & TemplatesFolder & "\" & FileToDelete) then
     ' Found the file, now establish whether containing folder is on the exempt list
     if NOT DeleteProtectedUsers then
     For Each element in protuserarray
       if ucase(element) = ucase(objSubfolder.Name) then
           DeleteFlag = "FALSE" ' mark this occurrence of the designated file as exempt from deletion
           exit for
       end if
       Next
     end if
     If DeleteFlag then
       ' File was found in a folder that is not exempt, so go ahead and attempt to delete 
      oFSO.DeleteFile sProfilesRoot & "\" & objSubfolder.Name & "\" & TemplatesFolder & "\" & FileToDelete,TRUE
     end if 
  end if
 Next
 ' Clean up before exiting
 set oFSO = Nothing
 set oWSH = Nothing





